Laminin-nidogen complex. Extraction with chelating agents and structural characterization

Extraction Heavy Metals from Contaminated Water Using Chelating Agents

Water pollution caused by toxic elements is one of the most important environmental problems in the world. Heavy metals are toxic to human and dangerous for the environment. The objectives of this study were: the effects of chelating agents on heavy metals extraction from polluted water were carried out to examine. In different concentrations : 0.01, 0.05, 0.1 mg/l of Chelating agents: Ethylene...

Synthesis and characterization of chelating agents responsible for tumor imaging

Present study shows the Rationale behind the synthesis of chelating agents and their thermodynamic stability along with kinetic inertness of metal complex in vivo is the prerequisites for the successful application of bifunctional chelating agentconjugate. Macrocyclic bifunctional chelating agents (BFCs) with their established stabilizing properties are in the forefront for radio-immuno applica...

Chromatographic Separations with Selected Supported Chelating Agents

Identification of Gln726 in nidogen as the amine acceptor in transglutaminase-catalyzed cross-linking of laminin-nidogen complexes.

The laminin-nidogen complex, the most abundant noncollagenous component of basement membranes, was recently shown to be a specific substrate for tissue transglutaminase (Aeschlimann, D., and Paulsson, M. (1991) J. Biol. Chem. 266, 15308-15317). Saturation experiments to determine the number of amine acceptor site(s) indicated a single reactive Gln residue in nidogen and none in laminin. Murine ...

Design of therapeutic chelating agents.

The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes w...